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KMID : 0357119790010010017
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Korean Journal of Immunology
1979 Volume.1 No. 1 p.17 ~ p.24
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Effects of Ascites and Pleural Effusions from Cancer Patients on the Rosette Formation of Healthy Human Peripheral Blood Lymphocytes
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河大有/Ha, Tai-You
鄭憲鐸/Chung, Hun-Taeg
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Abstract
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Non-specific suppressions of delayed-type hypersensitivities (DTH) measured by skin reactivity to certain antigens, response of lymphocytes to mitogens and spontaneous(E) rosette formation of lymphocytes with sheep red blood cells (SRBC) have been reported to occur in cancer bearing-patients. The mechanisms responsible for these immunosuppressions remain unclear, but some investigators suggested that the immunosuppressions may result from immunosuppressive factors exudated from tumor masses.
This study was undertaken to evaluate the effect of ascitic and pleural fluids from patients with cancers metastatic to peritonium or pleura. Non-cancerous ascitic and pleural effusions were used as controls.
The ascitic and pleural fluids from hepatoma patients and pulmonary carcinoma patients decreased not only the percentages of early and late rosette formations severely but also the affinity of lymphocytes to SRBC. On the other hand ascitic fluids from stomach cancer patients increased the percentages of early rosette formation and the affinity of lymphocytes to SRBC. Control effusions exerted no effect on rosette formation except the pleural effusions from pulmonary tuberculosis patients. Pleural effusions obtained from tuberculosis patients slightly increased the percentages of rosette formation and the affinity of lymphocytes to SRBC.
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